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Solution for Genome Editing in Mouse 
The application of CRISPR/Cas9 as a mammalian gene editing technology has matured considerably over the past decade. This has paved the way for the development of CRISPR/Cas9 as a therapeutic tool for the treatment of human genetic diseases while making it easier to create the gene editing animal models needed to screen potential therapies.
Genome editing can be performed in mice using a variety of techniques, including CRISPR/Cas9, TALEN, and ZFN, with CRISPR-Cas9 genome editing making it easy, fast, and effective to build accurate disease models. It has been used to generate knockout or knock-in mouse models in ES cells and fertilized eggs. In vivo delivery of CRISPR has been used to correct disease genes in mouse liver, and CRISPR technology has been used to engineer structural variants such as translocations, deletions, and inversions. CRISPR-Cas9 is a fast and flexible system that has the potential to accelerate the construction of accurate mouse models.
Fig. 1 Overview of CRISPR/Cas mediated mouse genome editing steps. (Harms DW, et al., 2014)
Solution
CRISPR/Cas9 PlatformCB has a professional project design team with artificial intelligence automated analysis system and an experienced and highly professionally trained experimental technology team. In order to provide you with the ideal animal model to meet your research needs from basic research to drug discovery, we always focus on gene editing and model development of model organisms. Our team of genetically engineered mouse models provides state-of-the-art services for the development and maintenance of gene editing mouse lines, including all modern genome editing tools and mouse gene editing expertise. We use CRISPR/Cas9 gene editing, which offers several advantages over traditional mouse gene editing techniques, including time savings, cost-effectiveness, and potentially reduced animal use. We continue to pursue new technologies and develop new resources for your preclinical research.
Our comprehensive services include strategy design, synthesis and preparation of molecular reagents, targeting vector construction, microinjection, screening and detailed genotyping analysis of mutant founders, and production of germline delivery F1 heterozygotes carrying the desired mutation. We are committed to providing high-standard solutions for genetically modified animal models, and we offer gene editing mice for the following research areas, including but not limited to
➢ CRISPR Mouse for Disease Modeling
- CRISPR Mouse for Cancer Modeling
- CRISPR Mouse for Neurodegenerative Disease Modeling
- CRISPR Mouse for Cardiovascular Disease Modeling
- CRISPR Mouse for Metabolic Disease Modeling
- CRISPR Mouse for Immunodeficiency Disease Modeling
➢ CRISPR Mouse for Drug Discovery
➢ CRISPR Mouse for Gene Function Research
Advantages of Our Technology
- Short cycle time and high efficiency
- High chimerism rate and reproductive genetic stability
- Enables DNA blockbuster knock-in
- Conditional knockout possible
- Enables large fragment knock-in
Related Services
- Conditional Knockout Mouse
- Conventional Knockout Mouse
- Point Mutation Mouse
- CRISPR/Cas9 Knockin Mouse
- Rosa26 Knockin Mouse
Related Products
Why Choose Us?
CRISPR/Cas9 PlatformCB is the leading technology platform in the field of gene editing services and animal/cell model generation. Our extensive research experience allows us to create a large number of humanized mouse models for research and drug screening, as well as provide custom mouse models. We guarantee high-quality technical support, customer service, products, fast turnaround times, and a 100% service guarantee. To learn more about our gene editing services and animal model generation, please feel free to contact us.
Reference:
- Harms DW, et al. Mouse Genome Editing Using the CRISPR/Cas System. Curr Protoc Hum Genet. 2014, 83:15.7.1-15.7.27.