CRISPR Rabbit for Infectious Disease Research    

The use of appropriate animal models is essential to simulate human infectious disease conditions, and all aspects including genetics, anatomy, and pathophysiology should be considered before selecting a model. Rabbits have become the primary experimental model for a number of human infectious diseases because of their susceptibility to infection and pathogenesis similar to that of humans. With the rapid development of rabbit genomics, proteomics, transgenic and knockout lines, and rabbit-specific reagents, the value of rabbits as experimental models in biomedical research is gradually increasing, particularly in their ability to bridge the gap between rodents and the large animal models often needed for preclinical and translational research.

Fig. 1 Illustration of the construction of the human immune system (HIS)-humanized rabbit models. (Song J, et al., 2020)

Solution

Creative Biogene can genetically edit rabbits with specific genetic mutations associated with infectious diseases through CRISPR/Cas9 technology. We are committed to providing you with valuable animal models for studying the pathology, immune response, transmission, and treatment of infectious diseases. We can provide the following CRISPR rabbit models for infectious disease research, including but not limited to

• CRISPR Rabbits for Human Papillomavirus Research
• CRISPR Rabbits for AIDS Research
• CRISPR Rabbits for Tuberculosis Research

What Can We Help You in Infectious Disease Research?

• Vaccine development: Our rabbit model allows for the development and testing of vaccines for infectious diseases by exposing them to pathogens and observing immune responses. We can also use CRISPR technology to modify specific genes encoding antigens to produce more effective vaccines.
• Studying host-pathogen interactions: Our CRISPR rabbit model can be used to study host-pathogen interactions during infection. By modifying specific host genes, we can help you study how these genes affect the immune response to pathogens and how they contribute to the development of disease.
• Drug development: Our CRISPR rabbit models can be valuable for drug development studies. For example, they can be genetically modified to develop specific diseases or sensitivity to pathogens, which can be used to test the efficacy of potential treatments.
• Disease transmission: Our CRISPR rabbit model can be used to study the transmission of infectious diseases from one individual to another. By modifying specific host genes, you can investigate the transmission of pathogens and the risk of infection.

Related Services

• Custom Rabbit Model

Related Products

• CRISPR/Cas9 Kits
• Cas9 Protein
• Cas9 mRNA
• Cas9 Related Plasmids
• Pre-made Cas9 Virus Particles

CRISPR/Cas9 Platform^CB is dedicated to providing important, reliable models for understanding human infectious and non-infectious diseases, including tuberculosis, syphilis and papillomavirus, herpesvirus, poxvirus, and norovirus infections, modified to promote immune responses to HSV-1 and HIV-1, to inform immunotherapy and vaccine development. If you are interested in our services, please feel free to contact us.