Our promise to you:
Guaranteed product quality, expert customer support.
24x7 CUSTOMER SERVICE
CONTACT US TO ORDER
CRISPR Rabbits for Tuberculosis Research 
Tuberculosis (TB) is a widespread human infection caused by Mycobacterium tuberculosis. The World Health Organization estimates that 1.5 billion people have latent TB infection, which can be reactivated in the presence of weakened host immunity, posing a threat to global TB control. Various animal models have been used to study the pathogenesis of tuberculosis. Although mice have an advantage in the laboratory, they are relatively resistant to TB infection. Unlike mice and guinea pigs, rabbits are the only animal model that can fully encapsulate the pathological features of human TB, including progressive disease with necrosis and cavity formation or the establishment of spontaneous latency. Thus, this model provides a way to study the factors that lead to this form of the disease and the bronchial transmission of the pathogen.
Fig. 1 Disease lesions in the rabbit model of pulmonary cavitary TB. (Rifat D, et al., 2018)
Solution
Creative Biogene uses CRISPR-Cas9 technology to develop rabbit models with specific genetic mutations associated with susceptibility or resistance to tuberculosis, and we are committed to helping you identify genes or genetic pathways critical to tuberculosis infection and understand the immune system's response to tuberculosis. In addition, our gene-edited rabbit model can be used to test potential treatments for TB. We can introduce therapeutic genes into the rabbit genome and observe the effects of these genes on infection, such as reducing the bacterial load in the lungs. In addition, our use of CRISPR-Cas9 gene editing technology in rabbits can help you conduct TB research that can accelerate the development of new therapies and vaccines for this infectious disease.
Related Analytical Services
Creative Biogene provides TB rabbit model development services using CRISPR/Cas9 technology, including conditional gene editing, knockout, knock-in, and conventional transgenic rabbit models. In addition, we offer related analytical services including but not limited to
- Bacterial growth and whole transcriptome analysis of rabbit lungs during infection
- Gene expression analysis of NK cell activation, DC maturation, and host cell antimicrobial defense network
- Gene expression analysis of macrophage and T cell activation and autophagic networks
- qPCR analysis of rabbit genes involved in Th1 and Th2 type immune responses
Advantages of Our Technology
- Accuracy: Our gene editing technologies such as CRISPR-Cas9 allow for the precise editing of specific genes with high precision, improving the accuracy and reproducibility of animal models.
- Customizability: Our gene editing technologies allow the creation of animal models with specific gene mutations, making it possible to more accurately mimic human diseases and conditions.
- Efficiency: Our gene editing technology allows for faster creation of genetically engineered animal models, which can help accelerate disease mechanism research and drug development.
- Cost reduction: Our gene editing technology allows for the production of genetically identical animals and reduces the cost of developing animal models.
Related Services
Related Products
CRISPR/Cas9 PlatformCB offers highly specialized services, including the development of rabbit models with specific gene mutations that mimic human tuberculosis using CRISPR-Cas9 gene editing technology and related analytical services. If you are interested in our services, please feel free to contact us.
Reference:
- Rifat D, et al. Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data. Sci Transl Med. 2018;10(435):eaai7786.