Comprehensive Disease Models for Preclinical Drug Discovery

Choosing the right cell model is half the battle won in your disease research and drug screening endeavors. Drug screening is a pivotal step in modern drug development processes, involving standardized experimental methods to sift through vast compounds and identify potential drug candidates with high activity against specific targets. Developing a new drug typically spans over a decade and entails substantial investments. Globally, over $30 billion is invested annually in new drugs, yet statistically, only one out of a million compounds eventually receive FDA approval for market launch, with only 30% of launched drugs recovering their R&D costs. Consequently, pharmaceutical companies place paramount importance on the efficiency and accuracy of their drug screening processes to reduce costs and accelerate drug development timelines.

Early in drug development, besides direct testing against known targets, cellular biological models play a crucial role throughout the screening process. Early elimination of negative compounds and identification of high-quality lead compounds are critical steps in drug screening that significantly mitigate development costs and risks.

Creative Biogene's Drug Screening Services

Creative Biogene is a leader in cell biology, providing cutting-edge cell-level testing solutions for drug discovery. We provide comprehensive cell screening and analysis services, including drug activity evaluation, ADME and pharmacokinetic testing, drug toxicity evaluation, etc. These services help to screen out negative compounds at an early stage and quickly identify high-quality lead compounds, thereby reducing development costs and risks.

Comprehensive Support Throughout the Drug Development Process

In addition, we provide multi-target drug screening services for various major targets, including but not limited to G protein-coupled receptors (GPCRs), nuclear receptors, kinases, ion channels, phosphodiesterases (PDEs), ubiquitin, proteases, and epigenetic-related targets. We also provide specific target cell lines services, such as GPCR and ion channel cell lines, to assist customers in compound screening and analysis of specific targets. At the same time, we also provide efficacy evaluation services using animal models such as mice, rats, and zebrafish to simulate the physiological and pathological characteristics of human diseases.

Our expertise covers a comprehensive range from 2D and 3D cell screening to animal model testing, providing full support for the entire drug development process, and helping you succeed in drug development.

Why Choose Our Drug Screening Services?

Extensive Cell Line Repository: With over 46,000 stable cell lines, we cater to diverse screening needs.
Rich Experience: 15 years of experience in constructing stable cell lines, providing robust support for your R&D.
High-throughput Screening Platforms: Equipped with advanced equipment ensuring efficient and high-quality screening results.
Short Detection Cycles: Rapid delivery of screening reports to expedite your drug development progress.
Cutting-edge Technologies: Utilization of the latest microfluidic drug screening models for leading-edge technical support.

Gene-Edited Cell Line Efficacy Evaluation

Using CRISPR-Cas9 technology, precisely edit specific genes to create cell lines with targeted gene knockouts or mutations. Thoroughly analyze the mechanism of action of candidate drugs in different genetic backgrounds, providing high-quality, reproducible research data. Ideal for studying drug efficacy in specific gene mutation cancers.

Drug-Resistant Cell Line Efficacy Evaluation

Offering a diverse library of drug-resistant cell lines, including those resistant to anticancer drugs. Evaluate the efficacy of candidate drugs in resistant backgrounds and assess their potential to reverse drug resistance, uncovering resistance mechanisms and therapeutic potential. Suitable for developing novel anti-resistance drugs and combination therapies.

Gene Fusion Cell Line Efficacy Evaluation

Focus on studying the role of gene fusion in cancer and targeted drug therapy. Provide various cell lines containing specific gene fusions, validate the inhibitory effects of candidate drugs through drug screening and mechanism studies, and comprehensively assess the therapeutic potential of drugs.

Animal Model Efficacy Evaluation

Utilizing animal models such as mice, rats, and zebrafish to simulate human diseases' physiological and pathological characteristics. Provide detailed efficacy assessment reports through in vivo drug testing and tumor growth inhibition experiments. Applicable for accurately assessing the in vivo efficacy and safety of candidate drugs, supporting preclinical studies.

Tell us about your R&D needs

Do not embark on your drug screening journey alone. Let Creative Biogene be your most reliable partner, providing solid assurance for your new drug development. Please contact us to learn more details, and we will provide customized solutions based on your requirements, ensuring reproducible results and helping protect your investments.

For research use only. Not intended for any clinical use.

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