CRISPR Rabbits for Nervous System Diseases Research    

Currently, neurological diseases are considered to be one of the leading causes of death and disability worldwide. Therefore, it is crucial to develop animal disease models that generalize to human neurological disorders. Compared to rodents, rabbits are phylogenetically closer to humans and more similar to humans in terms of brain development. The application of CRISPR/Cas9 gene editing technology in the study of rabbit neurological diseases is a promising and exciting development. This technology could be used to create rabbit models with specific gene mutations associated with neurological diseases such as Parkinson's disease or Alzheimer's disease.

Fig. 1 Development of the central nervous system in New Zealand rabbits. (de Almeida da Anunciação AR, et al., 2021)

Solution

Creative Biogene offers custom rabbit model development services using CRISPR/Cas9 technology. Our services include the use of CRISPR/Cas9 technology to create single or multiple gene edits that result in knockout or knock-in rabbit models. We genetically modify rabbits using CRISPR/Cas9 technology to produce disease symptoms of neurological disorders, which can then be studied and tested to help you better understand the pathogenesis of neurological disorders. In addition, our gene-edited rabbit models can be used to study the effects of potential therapeutic drugs and treatments on neurological disorders. By knocking out a particular therapeutic gene in the rabbit genome, we allow you to observe the effect of this gene on disease development and progression. Overall, our CRISPR/Cas9 technology has the potential to advance the development of therapies and treatments for neurological disorders.

Advantages of Rabbits as Animal Models for Neurological Diseases

• Rabbits are phylogenetically closer to humans than rats.
• Compared to rodents, rabbits have greater similarity in central nervous system development to humans.
• Rabbits are relatively large, making them easy to handle and sample.
• Rabbits live long enough to observe disease progression.

Related Services

• Custom Rabbit Model

Related Products

• CRISPR/Cas9 Kits
• Cas9 Protein
• Cas9 mRNA
• Cas9 Related Plasmids
• Pre-made Cas9 Virus Particles

CRISPR/Cas9 Platform^CB provides custom rabbit model development services through CRISPR/Cas9 technology. Our services include gene editing and transgenic rabbit model development. We can perform the most complex genetic manipulations in rabbits using CRISPR/Cas9 technology, including point mutations, large fragment substitutions, large fragment deletions, conditional KO, etc.

We are dedicated to developing targeted genome editing rabbit models for human neuronal diseases, including models of neurological disorders such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, Alzheimer's disease, and microcephaly caused by the Zika virus. We also offer research and testing services to help you more quickly identify new targets for potential therapies for neurological disorders. If you are interested in our services, please feel free to contact us.