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"Light shines, and the tumor shrink". It may sound like a science fiction, or the way of exaggerating thing. But in fact, this is the result after careful study by researchers from the Rochester College. They applied a very novel and effective weapon—optogenetics into the field of cancer immunotherapy, effectively alleviating the immune inhibition in solid tumor micro-environment and minifying the tumor significantly.
An international team led by KAUST found an epigenetic mechanism for regulating gene activity in the study of the adult genomes and their interactions with environment.
In a new study, researchers from the Karolinska Institute in Sweden mapped how different DNA-binding proteins in human cells respond to certain biochemical modifications of DNA molecules. They reported that some of the major regulatory proteins were able to activate regions of the genome that were not active in the normal case due to epigenetic changes. Their findings helped better understand the process of gene regulation, embryonic development and diseases leading to cancer. The results of the study were published in the Science on May 5, 2017, entitled "Impact of cytosine methylation on DNA binding specificities of human transcription factors".
Gene editing is a genetic engineering technique, which is pointed to a sequence without knowing the function of it, by altering the genetic gene of a living organism to reduce the effect of a particular gene function. By studying the effects on the organism, we can find the biological function of genes.
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Roche 454
Illumine
It has been over 30 years since the first generation of DNA sequencing technology was developed in 1977. During this period, sequencing technology has made considerable progress. From the first generation to the third generation and even the fourth generation, sequencing technology has experienced the read length from long to short, and short to long. Although the second generation---short-read sequencing technology still dominates the current global sequencing market, the third and fourth generation of sequencing technologies are rapidly evolving over the course of the two-year period. Every transformation of sequencing technology results in a huge role in promoting genome research, disease medical research, drug development, breeding and other fields. This blog is mainly focusing on the current genome sequencing technologies and their sequencing principles.
