• Adenovirus Service • AAV Service • Lentivirus Service • Retrovirus Service
The CRISPR-Cas system is an adaptive immune system of bacteria and archaea that can resist the invasion of viruses and mobile genetic elements. Although the DNA targeting mechanisms of CRISPR-Cas9 and CRISPR-Cas12 systems have been widely studied, the evolutionary origin of the RNA-targeted CRISPR-Cas13 system is still unclear.
Current lipid nanoparticle (LNP) drug delivery technologies are formulated with ingredients such as cholesterol that are destined to accumulate in the liver, which is why many established genetic medicines (such as gene therapy, mRNA vaccines and gene editing technologies) are excreted before they reach their targets. If you want to treat brain diseases or lung diseases, you don't want the delivered drugs to go to the liver. This requires the development of solutions that can target drugs to the right tissues and cells.
The 2024 Nobel Prize in Physiology or Medicine was first announced on October 7. The winners are Victor Ambros and Gary Ruvkun. They won the prize for their discovery of microRNA and its role in post-transcriptional gene regulation.
Antisense oligonucleotides (ASOs) are a new generation of drugs that can treat human diseases by blocking the transmission of harmful information from the body's genes. In cancer patients, ASOs have the potential to block messages that drive tumors to grow and spread. However, ASOs have not yet been used to treat human cancer. First, they must be transported into cancer cells, but the cancer cells will not let them in.
When symptoms do occur, they may be mistaken for other illnesses — such as the flu — and usually begin four to 10 days after you are bitten by an infected mosquito. Dengue fever causes a high fever — 104 F (40 C) — and any of the following signs and symptoms:HeadacheMuscle, bone or joint painNauseaVomitingPain behind the eyesSwollen glandsRash
In terms of drug development, currently, the most frequently used gene editing technology is the preparation of animal models.
In a recent study, researchers at the University of California, San Francisco described the first concrete example of how a microbiome can interfere with the intended effects of a drug. They focus on L-dopa, the main treatment for Parkinson's disease, which identifies which of the trillions of bacteria are responsible for degrading drugs and how to prevent this microbial interference.
"Light shines, and the tumor shrink". It may sound like a science fiction, or the way of exaggerating thing. But in fact, this is the result after careful study by researchers from the Rochester College. They applied a very novel and effective weapon—optogenetics into the field of cancer immunotherapy, effectively alleviating the immune inhibition in solid tumor micro-environment and minifying the tumor significantly.
Gene editing is a genetic engineering technique, which is pointed to a sequence without knowing the function of it, by altering the genetic gene of a living organism to reduce the effect of a particular gene function. By studying the effects on the organism, we can find the biological function of genes.
