• Adenovirus Service • AAV Service • Lentivirus Service • Retrovirus Service
An international team led by KAUST found an epigenetic mechanism for regulating gene activity in the study of the adult genomes and their interactions with environment.
In a new study, researchers from the Karolinska Institute in Sweden mapped how different DNA-binding proteins in human cells respond to certain biochemical modifications of DNA molecules. They reported that some of the major regulatory proteins were able to activate regions of the genome that were not active in the normal case due to epigenetic changes. Their findings helped better understand the process of gene regulation, embryonic development and diseases leading to cancer. The results of the study were published in the Science on May 5, 2017, entitled "Impact of cytosine methylation on DNA binding specificities of human transcription factors".
DNA methylation is a common modified approach discovered early by scientists in the field of molecular biology. A large number of studies have shown that DNA methylation can regulate gene expression by causing changes to chromatin structure, DNA conformation and stability, as well as the interactions between DNA and proteins.
Summary
