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mitfa

Official Full Name
melanocyte inducing transcription factor a
Organism
Danio rerio
GeneID
30080
Background
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within with a positive effect on melanocyte differentiation. Acts upstream of or within several processes, including cellular response to tumor cell; closure of optic fissure; and positive regulation of melanocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; iridoblast; melanoblast; neural crest; and pigment cell. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg syndrome; Waardenburg syndrome type 2A; and familial melanoma. Orthologous to human MITF (melanocyte inducing transcription factor). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
nacre; z3A.1;

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