Creative Biogene is a leading biotechnology company in the field of transporters screening and profiling services.
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Creative Biogene is a leading biotechnology company in the field of transporters screening and profiling services. With years of experience and innovation of transporters compounds assays, we can offer a wide range of targets coverage to help you fulfill transporters drug discovery project effectively and high-quality.
Creative Biogene has built various platforms to overcome the challenges associated with transporter assays. We offer a broad of transporter screening assays, including FDA transporter panel, monoamine transporter models and many other cell models. Moreover, Creative Biogene has developed robust transporters uptake and inhibition assays to allow screening of new molecular entities (NMEs) for their interactions with transporters quickly and effectively.
Transporters are a kind of membrane proteins controlling uptake and efflux of essential nutrients ions, neurotransmitters, cellular waste, environmental toxins, and drugs, into and out of cells and organelles. Therefore, transporters play a significant important role in drug's clinical efficacy and safety. Currently, transporters are used as therapeutic targets to treat numerous diseases such as diabetes, asthma, cardiovascular diseases, major depression, neuroscience, hypertension and constipation.
In human genome, more than 400 membrane transporters are annotated. Generally, membrane transporters are divided into two major super-families, the ATP binding cassette (ABC) family and the solute carrier (SLC) family. Preclinical and clinical studies indicate that transport is an important determinant of drug disposition, as well as therapeutic and adverse drug effects (KM, et al. 2013).
Fig.1 The Structure of ABC transporter
Creative Biogene offers various platforms and detection formats for transporter drug discovery, including but not limited to the following categories:
Advantages of transporters screening and profiling in Creative Biogene:
Creative Biogene offers availability of various panels for screening and profiling of transporters compounds. Our experienced and talented scientists are dedicated to help you identify the compounds with the greatest chance to success. Creative Biogene has delivered a plenty of services to meet your demands of transporters compounds screening. We are confident in accelerating your drug discovery projects and providing you results with fast turnaround time and high-quality.