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Ubiquitination is a fundamental post-translational modification that regulates cellular physiology by covalently attaching ubiquitin to substrate proteins. This precise enzymatic cascade is orchestrated by E1 activating enzymes, E2 conjugating enzymes, and E3 ubiquitin ligases, enabling tight control over protein stability, localization, activity, and interactions. The reverse process, catalyzed by deubiquitinases (DUBs), removes ubiquitin or edits ubiquitin chains to maintain dynamic cellular balance.
The complexity of ubiquitin signaling extends far beyond protein degradation, encompassing diverse chain topologies (K48, K63, K11, linear, and mixed linkages) that constitute a finely tuned "ubiquitin code" recognized by specific receptor proteins. This code governs key biological processes, including DNA damage response, cell cycle progression, immune signaling, and protein quality control.
Figure 1. Schematic of key events in ubiquitylation and deubiquitylation. (Harrigan JA, et al., 2017)
Dysregulation of ubiquitin pathway components is closely linked to numerous diseases. Mutations in E3 ligases and aberrant DUB activity are implicated in cancer, neurodegenerative disorders, inflammatory diseases, and metabolic syndromes. The recent rise of targeted protein degradation technologies, including bifunctional degraders and molecular glues, further underscores the therapeutic potential of manipulating ubiquitin-mediated protein homeostasis.
Creative Biogene provides specialized screening and characterization services to support research on ubiquitin system components, accelerating technological development in this rapidly evolving therapeutic area.
Our platform enables systematic analysis of all major DUB families:
DUB Functional Analysis and Profiling
Our services include:
We support functional studies of E3 ligases through:
Our services leverage state-of-the-art methodologies:
Creative Biogene adheres to a collaborative scientific philosophy:
To learn how our ubiquitin screening and profiling services can advance your research programs, please reach out to our scientific team. We look forward to collaborating on challenging projects and providing tailored solutions to meet your specific research needs.
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