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TP53

Official Full Name
tumor protein p53
Background
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
Synonyms
TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53; Li Fraumeni syndrome; mutant p53 protein; truncated p53 protein; tumor suppressor TP53; FLJ92943; tumor suppressor p53; brp53; drp53; fb40d06; wu:fb40d06; zgc:111919; etID22686.5

Cat.No. Product Name Price
CLKO-0119TP53 KO Cell Lysate-HeLaInquriy
CLKO-0965TP53 KO Cell Lysate-HEK293TInquriy

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